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Patient-Centered Research

HealthCore Impact Study: Innovative Approaches to Gathering the Patient Perspective

HealthCore’s Patient-Centered Research (PCR) team goes beyond numbers to inform meaningful research solutions with rich, in-depth insights. HealthCore utilizes a unique mix of expertise, access to claims data, and relationships in the design and conduct of patient-centered research for the purpose of improving patient health and outcomes.

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Health Economics & Outcomes Research

Clinical Oncology Research Solutions

HealthCore’s data environment, relationships, and research expertise position us to deliver high-quality, actionable results, saving you time and effort. We can partner with you to generate relevant evidence that has a meaningful impact for many healthcare decision makers.

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Safety & Epidemiology

Causal Inference for Real-World Evidence

Causal inference is used to answer cause and effect research questions and yield estimates of effect. These study design considerations and statistical methods address the effects of confounding variables and other potential biases, and allow researchers to answer questions such as, “Does treatment A produce better patient outcomes as compared to Treatment B?”

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Research Position

A Letter from the President: Our Next Chapter

HealthCore is joining the Carelon family of brands under Elevance Health and will continue to focus on supporting the need for evidence generation and research collaboration in the marketplace.

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Safety & Epidemiology

HealthCore Impact Study: Using Background Incidence Rates to Inform Vaccine Safety

RCTs are comparative studies that use randomization and scientifically rigorous methods that are sufficient for approval-related decision making. However, these studies may not have sufficient sample sizes to detect rare adverse events or may exclude people with certain characteristics. Researchers then turn to real-world data (RWD) to gather more information on vaccines and monitor their safety and effectiveness in practice.

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Health Economics & Outcomes Research

HealthCore Impact Study: Validation of Integrated Claims and Clinical Oncology Data

In celebration of HealthCore’s 25th Anniversary of Founder’s Day, we’re rolling out a series of articles highlighting some of our most impactful work.

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Health Economics & Outcomes Research

What is Causal Inference and When Do You Need It?

Causal inference with observational data combines numerous theoretical and technical concepts, necessitating specialized training and competency. HealthCore offers highly specialized scientists, access to a robust source of integrated real-world data, and decades of experience successfully employing these concepts and methods.  

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Patient-Centered Research

Listening to Patients: Developing Patient-Reported Outcome Measures to Improve Patient Care

Not only are PROMs seen as necessary and valuable in evaluating efficacy in drug and device trials, but they are also recognized as irreplaceable in many clinical research areas because they provide data that cannot be captured any other way.

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Clinical Research

HealthCore Impact Study: Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome

In celebration of HealthCore’s 25th Anniversary of Founder’s Day, we’re rolling out a series of articles highlighting some of our most impactful work.

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Safety & Epidemiology

HealthCore Impact Study: A Sentinel Data Partner and Scientific Collaborator

In celebration of HealthCore’s 25th Anniversary of Founder’s Day, we’re rolling out a series of articles highlighting some of our most impactful work.

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Patient-Centered Research

Survey Research: Elements of a “Good” Survey

Survey research is a critical component of patient-centered research involving gathering information systematically from individuals by asking them questions about a specific topic or topics and generalizing the results to a larger population.

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Health Economics & Outcomes Research

HealthCore Impact Study: Cost-Effectiveness of a Proteomic Test for Preterm Birth Prediction

In celebration of HealthCore’s 25th Anniversary of Founder’s Day, we’re rolling out a series of articles highlighting some of our most impactful work.

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Collaborations

What is Real-World Evidence and Why is It Important?

Real-world data and real-world evidence are more than just buzzwords. They’re becoming increasingly important for informing healthcare decisions across a number of settings and stakeholders.

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Health Economics & Outcomes Research

What is Real-World Evidence and Why is It Important?

Real-world data and real-world evidence are more than just buzzwords. They’re becoming increasingly important for informing healthcare decisions across a number of settings and stakeholders.

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Safety & Epidemiology

HealthCore Impact Study: Topiramate Use in Pregnancy and the Birth Prevalence of Oral Clefts

In celebration of HealthCore’s 25th Anniversary of Founder’s Day, we’re rolling out a series of articles highlighting some of our most impactful work.

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Research Position

HealthCore Celebrates 25th Anniversary of Founder’s Day: A Letter from the President

Twenty-five years have passed since we set out on this journey and though there continues to be significant work ahead of us, the understanding of the need for RWE within the scientific and medical community is firmly rooted. Our mission to advance the derivation and utilization of RWE continues and we are excited about the future of RWE.

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Safety & Epidemiology

Real-World Evidence Complements Randomized Clinical Trials to Enhance Drug Safety and Effectiveness

Recently, researchers from the Safety and Epidemiology team at HealthCore conducted one of the first real-world studies investigating the safety of palbociclib, the most widely prescribed CDK4/6 inhibitor in the treatment of HR+/HER2- advanced stage breast cancer.

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Collaborations

The Value of Dental and Medical Benefit Integration

Research has shown that people with good oral health generally have better overall health. This white paper outlines Elevance Health activities designed to improve oral health, and the impact these activities can have on overall health and costs.

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Safety & Epidemiology

Predictive Modeling and Machine Learning: Sharpening the Focus of Real-World Evidence in the Age of Precision Medicine

Real-world evidence can usefully support precision medicine and faster regulatory approvals. The use of statistical methods to develop better case-identifying algorithms enables use of claims databases to study rare diseases and other targeted indications as well as more valid outcome ascertainment for safety and effectiveness research.

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Health Economics & Outcomes Research

Predictive Modeling and Machine Learning: Sharpening the Focus of Real-World Evidence in the Age of Precision Medicine

Real-world evidence can usefully support precision medicine and faster regulatory approvals. The use of statistical methods to develop better case-identifying algorithms enables use of claims databases to study rare diseases and other targeted indications as well as more valid outcome ascertainment for safety and effectiveness research.

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Collaborations

The Value of Pharmacy and Medical Benefit Integration

As health care costs continue to rise, employers and payers are under increasing cost pressure to optimally manage their members’ care. This White Paper explores the impact of integrated Elevance Health medical and pharmacy benefits on medical costs.

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Clinical Research

Optimizing Real-World Evidence in Medical Device Development

As RWD and RWE continue to rise in popularity and adoptability, it’s important to understand the benefits and applicability to stakeholders.

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Collaborations

Study Demonstrates How Reducing Consumer Out-of-Pocket Costs for Primary Care Improves the Consumer Experience

To better understand the potential health and financial benefits of VBID models for consumers, we evaluated the impact of a large employer’s decision to remove employee and dependents’ out-of-pocket costs for primary care physician (PCP) visits.

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Collaborations

Expertise in Rare and Orphan Disease Research

Our Clinical Research experts have worked collaboratively in complex studies of rare/orphan diseases with multi-specialty teams and multiple stakeholders. Offerings to our clients include customized clinical trials, epidemiology, health and policy research, and patient registry services.

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Clinical Research

Expertise in Rare and Orphan Disease Research

Our Clinical Research experts have worked collaboratively in complex studies of rare/orphan diseases with multi-specialty teams and multiple stakeholders. Offerings to our clients include customized clinical trials, epidemiology, health and policy research, and patient registry services.

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Collaborations

Sometimes Less Is More . . . at Least When It comes to Radiation Therapy for Breast Cancer

Early-stage breast cancer patients often need radiation therapy as part of their treatment. Evidence on how long the radiation treatment should last has been evolving. Our results highlight that payor policies can significantly accelerate adoption of evidence-driven care above and beyond what physicians are doing on their own.

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Life Sciences

HEOR Trends: Real-World Evidence and Value-Driven Healthcare

As real-world evidence is increasingly used to inform healthcare decision making, including regulatory decisions, robust methodology is becoming ever more critical.

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Health Economics & Outcomes Research

HEOR Trends: Real-World Evidence and Value-Driven Healthcare

As real-world evidence is increasingly used to inform healthcare decision making, including regulatory decisions, robust methodology is becoming ever more critical.

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Life Sciences

The Power of Machine Learning

Machine learning combines advanced statistical methods with the results from validation studies to construct new case-identifying algorithms. We have found these methods to offer marked improvement in the accuracy with which we can identify patients of interest. These methods not only reduce bias from misclassification, which translates into more valid research, but we have also been able to identify patients with conditions for which there are no diagnosis codes in claims, such as cancer stage or biomarker status.

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Safety & Epidemiology

The Power of Machine Learning

Machine learning combines advanced statistical methods with the results from validation studies to construct new case-identifying algorithms. We have found these methods to offer marked improvement in the accuracy with which we can identify patients of interest. These methods not only reduce bias from misclassification, which translates into more valid research, but we have also been able to identify patients with conditions for which there are no diagnosis codes in claims, such as cancer stage or biomarker status.

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Life Sciences

Changing the Clinical Trial Paradigm for Rare and Orphan (R&O) Diseases using Real-World Evidence

Dr. Patti Peeples, CEO of HealthEconomics.Com, sat down with Flora Sandra Siami, MPH, Vice President of Clinical Research, Regulatory Affairs, and Quality Assurance at HealthCore.

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Clinical Research

Changing the Clinical Trial Paradigm for Rare and Orphan (R&O) Diseases using Real-World Evidence

Dr. Patti Peeples, CEO of HealthEconomics.Com, sat down with Flora Sandra Siami, MPH, Vice President of Clinical Research, Regulatory Affairs, and Quality Assurance at HealthCore.

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Government

Moving Research to Reality

The rapid pace of technological development will continue to drive global change in health care as well as the meaning of personalized, precision medicine. We are uniquely positioned to be a leader in this dynamic evolution with our depth of scientific expertise, breadth of knowledge in digital strategies, and decades of commitment to dissemination and implementation approaches.

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Government

A Leader in Pediatric Research for 30 Years

Since its founding, our clinical research team has been deeply involved in the long-standing effort to improve these figures by conducting, or collaborating on, research in children and infants.

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Clinical Research

A Leader in Pediatric Research for 30 Years

Since its founding, our clinical research team has been deeply involved in the long-standing effort to improve these figures by conducting, or collaborating on, research in children and infants.

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Government

PTSD Clinicians Exchange: Improving Adoption of Technology-based Resources

Our Digital team has been a proud partner of the VA and the Department of Defense (DoD) on several projects which built and evaluated a provider registry that will support clinicians who treat veterans and active duty military personnel with PTSD.

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Government

Physicians Treating Patients in PCMH’s Offered Enhanced Patient Care, Even during Early Transformation

Most patient-centered medical homes studies are limited to measuring whether patients have their cholesterol levels taken, receive their HbA1c testing, and reporting their values. HealthCore went beyond these to measure whether patients with diabetes and cardiovascular disease had better health outcomes.

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Comparative Effectiveness

Seven Low-Value Services to Look Out For

Reducing low-value services can help make healthcare more affordable over time without compromising the health outcomes of patients. The Choosing Wisely Campaign is a national initiative that seeks to advance a national dialogue on avoiding unnecessary medical tests, treatments, and procedures. HealthCore conducted a claims-based analysis to determine the effectiveness of this campaign on seven of the earliest low-value services.

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Life Sciences

Improving Clinical Trial Recruitment & Retention

The best-designed clinical trial is only as good as the subjects it enrolls…and retains. Recognizing this fundamental truth led our team to create in-house expertise in subject recruitment and retention, and to build a digital solutions resource center to sup¬port these efforts.

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Life Sciences

Taking Data to the Cleaners

Research data can come in all degrees of “cleanliness.” Clean data are free of errors, out-of-range values, missing values, or misplaced values. It turns out that much can be done to improve the “cleanliness” of data — and our Resource Operations team is at the forefront of such efforts.

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Clinical Research

Taking Data to the Cleaners

Research data can come in all degrees of “cleanliness.” Clean data are free of errors, out-of-range values, missing values, or misplaced values. It turns out that much can be done to improve the “cleanliness” of data — and our Resource Operations team is at the forefront of such efforts.

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Life Sciences

The Value of Pragmatic Trials to Regulators

HealthCore looks forward to the potential, positive impact that real-world evidence may have on regulatory decision making and therapeutics development within the U.S.

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Research Position

The Value of Pragmatic Trials to Regulators

HealthCore looks forward to the potential, positive impact that real-world evidence may have on regulatory decision making and therapeutics development within the U.S.

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Life Sciences

The Value of Pragmatic Trials to Life Science Product Developers

We believe pragmatic trials will be a large part of the future of outcomes research – to understanding life science products in real-world settings, evaluating comparative effectiveness and helping to improve patient care.

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Research Position

The Value of Pragmatic Trials to Life Science Product Developers

We believe pragmatic trials will be a large part of the future of outcomes research – to understanding life science products in real-world settings, evaluating comparative effectiveness and helping to improve patient care.

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Life Sciences

The Value of Pragmatic Trials to Clinicians

Pragmatic clinical trials provide the optimal environment to address a broad spectrum of real-world issues, and generate evidence synergistic and complementary to RCTs. For clinicians, pragmatic trials generate evidence that enables better-informed decision making.

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Research Position

The Value of Pragmatic Trials to Clinicians

Pragmatic clinical trials provide the optimal environment to address a broad spectrum of real-world issues, and generate evidence synergistic and complementary to RCTs. For clinicians, pragmatic trials generate evidence that enables better-informed decision making.

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Collaborations

Real-World Evidence: Enriching the Gold Standard

Under certain circumstances, opening up the design options in the pre-approval phases of drug development to include Pragmatic Clinical Trials (PCT’s) has the potential to greatly enrich and complement the findings from traditional RCT’s and, earlier in the drug approval process, broaden the generation of evidence more relevant to treated patients.

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Research Position

Real-World Evidence: Enriching the Gold Standard

Under certain circumstances, opening up the design options in the pre-approval phases of drug development to include Pragmatic Clinical Trials (PCT’s) has the potential to greatly enrich and complement the findings from traditional RCT’s and, earlier in the drug approval process, broaden the generation of evidence more relevant to treated patients.

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Collaborations

Collaboration: A Key Driver of Change in Healthcare

Large-scale alliance collaborations present a massive opportunity for stakeholders to work together to inform the decisions that have the power to make healthcare safer, lower cost, and higher quality.

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Research Position

Collaboration: A Key Driver of Change in Healthcare

Large-scale alliance collaborations present a massive opportunity for stakeholders to work together to inform the decisions that have the power to make healthcare safer, lower cost, and higher quality.

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Life Sciences

HEOR Trends: Going Broad and Deep in Real-World Evidence

Traditional methods of generating evidence, from single data sources and perspectives, often no longer meet the needs of our complex health system. HealthCore has the data assets and expertise necessary for going broad and deep in real-world evidence generation.

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Health Economics & Outcomes Research

HEOR Trends: Going Broad and Deep in Real-World Evidence

Traditional methods of generating evidence, from single data sources and perspectives, often no longer meet the needs of our complex health system. HealthCore has the data assets and expertise necessary for going broad and deep in real-world evidence generation.

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Life Sciences

The Growing War against Opioids

As these various efforts to address the growing problem of prescription drug abuse and misuse play out, it will be important to monitor the degree to which they succeed in the real world. Safety and Epidemiology research is providing insights into the effectiveness of these efforts.

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Safety & Epidemiology

The Growing War against Opioids

As these various efforts to address the growing problem of prescription drug abuse and misuse play out, it will be important to monitor the degree to which they succeed in the real world. Safety and Epidemiology research is providing insights into the effectiveness of these efforts.

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Collaborations

Staying Ahead of the Technology Curve in Digital Research Solutions

From its inception, the mission of our Digital Research Solutions team has been the dissemination of important research findings to target audiences ranging from underserved populations, to providers and policy makers.

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Collaborations

Some Progress Made, but More to Do Ahead

With ADHD diagnosis and medication prescriptions on the rise, it is crucial to better understand the trend for diagnosis and treatment pattern for ADHD among American children over time.

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Government

Use of Biosimilar Growth Factor Increases in Supportive Cancer Care

Interview with Abiy Agiro, PhD, Director, Comparative Effectiveness, Translational Research at HealthCore, Inc.

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